Human Health Risk Assessment (HHRA)
Objectives
The objective of the Human Health Risk Assessment is to select ingredients that will be used in our products that are safe for workers and for consumers. Part of the assessment always is to anticipate accidents and potential for misuse. For any of the human health effects, a no effect level is established.
The relevant human health endpoints most commonly addressed are: acute oral and dermal toxicity, skin irritation, eye irritation, sensitisation potential, mutagenicity, reproductive toxicity, neurotoxicity
and carcinogenicity .
We rely on a two key numbers for each endpoint in the human health risk assessment:
The comparison of the exposure with the no effect level is used as an indicator of risk and can be expressed as the risk quotient or the safety margin.
The relevant human health endpoints most commonly addressed are: acute oral and dermal toxicity, skin irritation, eye irritation, sensitisation potential, mutagenicity, reproductive toxicity, neurotoxicity
and carcinogenicity . We rely on a two key numbers for each endpoint in the human health risk assessment:
The comparison of the exposure with the no effect level is used as an indicator of risk and can be expressed as the risk quotient or the safety margin.
Definition
Human Health Risk Assessment (HHRA) is a tiered process that progresses from the use of short-term tests (acute oral and dermal toxicity, skin and eye irritation, mutagenicity , sensitisation potential) and conservative assumptions to longer-term (chronic) tests paired with more realistic assumptions.
HHRA continues until either of the following outcomes is reached:
, sensitisation potential) and conservative assumptions to longer-term (chronic) tests paired with more realistic assumptions.HHRA continues until either of the following outcomes is reached: